[1]侯利红,殷艳玲△.硝苯地平联合复方罗布麻颗粒治疗原发性高血压疗效研究[J].陕西医学杂志,2018,(11):1483-1486.
　Hou Lihong,Yin Yanling..The symptom improvement and curative effect of Luobuma granules combined with Nifedipine in essential hypertension patients[J].,2018,(11):1483-1486.
点击复制

硝苯地平联合复方罗布麻颗粒治疗原发性高血压疗效研究
分享到：

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1483-1486
栏目:
药物与临床
出版日期:
2018-11-29

文章信息/Info

Title:
The symptom improvement and curative effect of Luobuma granules combined with Nifedipine in essential hypertension patients
文章编号:
0.3969/j.issn.1000-7377.2018.11.035
作者:
侯利红1; 殷艳玲2△
1.西安市第三医院康复医学科（西安 710016）,2.西安市第三医院神经内科(西安 710016）
Author(s):
Hou Lihong; Yin Yanling.
Rehabilitation Medicine of Xi’an Third Hospital ( Xi’an 710016)
关键词:
高血压/药物疗法硝苯地平/治疗应用罗布麻/治疗应用
Keywords:
Hypertension/drug therapyNifedipine/therapeutic useApocynum venetum/therapeutic use
分类号:
R544.1
文献标志码:
A
摘要:
目的：研究硝苯地平联合复方罗布麻颗粒对原发性高血压（EH）患者的症状改善及疗效评价。方法：选取EH患者270例，对照组服用硝苯地平缓释片，观察组在服用硝苯地平缓释片的基础上，服用复方罗布麻颗粒。两组患者使用右臂测量血压，比较治疗前后的血压值。对患者的疗效进行评价，并计算治疗有效率。对患者进行血流动力学测定，测定治疗前后的左室收缩和心脏舒张功能，包括左心室射血分数（EF）、左心室缩短率（FS）、心排出量（SV）和CO（每分钟心输出量）。使用汉密尔顿焦虑量表（HAMA）对两组患者的焦虑程度进行评定，并记录出现的头痛、脸红等副反应。结果：治疗后，对照组和观察组患者的舒张压和收缩压都有显著性下降（P＜0.05），与对照组相比，观察组显著较低（P＜0.05）。对照组的治疗总有效率显著低于观察组（P＜0.05）。治疗后，对照组和观察组的EF、FE、SV和CO值都显著增大（P＜0.05）。与对照组相比，治疗后观察组的EF、FE、SV和CO值显著高于对照组（P＜0.05）。治疗后，对照组和观察组的焦虑评分均显著降低，其中观察组降低程度更大（P＜0.05）。治疗过程中，对照组不良反应发生率为13.33%，观察组不良反应发生率为5.92%，观察组的不良反应发生率显著低于对照组（χ2=4.256，P=0.039）。 结论：硝苯地平联合复方罗布麻颗粒能够有效地降低患者血压，提高治疗有效率，改善心功能，缓解患者的焦虑情绪，且安全性较高。
Abstract:
Objective：The symptom improvement and curative effect of Luobuma granules combined with Nifedipine in essential hypertension patients were studied in this paper. Methods：270 patients were selected for EH treatment in our hospital, nifedipine sustained-release tablets were administered to the control group, and the observation group took compound luobuma granules on the basis of nifedipine sustained-release tablets. Two groups of patients used the right arm to measure blood pressure and compare blood pressure before and after treatment. The curative efficacy of patient and effectiveness of the treatment were evaluate. Hemodynamic measurements were performed to determine left ventricular systolic and diastolic function before and after treatment, including left ventricular ejection fraction (EF), left ventricular shortening (FS), cardiac output (SV), and CO ( Heart output per minute). The Hamilton Anxiety Scale (HAMA) were used to assess the anxiety degree of the two groups of patients, and to record the occurrence of headaches, blush and other side effects. Results：After treatment, the diastolic blood pressure and systolic blood pressure of the control group and the observation group were significantly decreased (P＜0.05), compared with the control group, the observation group was significantly lower (P＜0.05). The total effective rate of treatment in the control group was significantly lower than that in the observation group (P＜0.05). After treatment, the EF, FE, SV and CO values of the control group and the observation group were significantly increased (P＜0.05). Compared with the control group, the EF, FE, SV and CO values of the observation group after treatment were significantly higher than those of the control group (P＜0.05). After treatment, the anxiety scores of the control group and the observation group were significantly reduced, and the observation group was more severely reduced (P＜0.05). During the course of treatment, the incidence of adverse reactions was 13.33% in the control group and 5.92% in the observation group. The incidence of adverse reactions in the observation group 〖LM〗was significantly lower than that in the control group (χ2=4.256, P=0.039). Conclusion：Compound Luobuma granules combined with nifedipine can effectively reduce blood pressure in patients, improve treatment efficiency, improve cardiac function, relieve anxiety in patients with high safety, and can be further promoted in the clinic.

参考文献/References:

[1]刘佳梅,刘佳,蔡军,等.原发性高血压相关代谢组学的初步研究[J].中华高血压杂志,2016,24(4)：340-347.
[2]田孝弟,田瑞琴.降压散敷脐联合硝苯地平治疗高血压病30例[J]. 陕西中医, 2013, 34(6):732-733.
[3]孔娜娜,方圣涛,刘莺,等.罗布麻叶中非黄酮类化学成分研究[J].中草药,2013,44(22):3114-3118.
[4]Singh M,Singh AK,Pandey P,et al.Molecular genetics of essential hypertension[J].Clinical & Experimental Hypertension, 2016, 38(3):268-277.
[5]刘力生. 2004年中国高血压防治指南(实用本)[J]. 中华高血压杂志, 2004, 12(6):1060-1064.
[6]Singh M,Singh AK,Pandey P,et al.Molecular genetics of essential hypertension[J].Clinical & Experimental Hypertension, 2016, 38(3)：268-277.
[7]周函.苯磺酸左旋氨氯地平对轻、中度原发性高血压的疗效和安全性分析[J]. 陕西医学杂志, 2014，43(4)：487-488.
[8]Bruno RM, Duranti E, Ippolito C, et al. Different Impact of Essential Hypertension on Structural and Functional Age-Related Vascular ChangesNovelty and Significance[J]. Hypertension, 2017, 69(1):116-118.
[9]冯建海. 硝苯地平缓释片联合依那普利治疗老年冠心病合并高血压的疗效观察[J].河北医药,2016,38(15)：2330-2332.
[10]Gco F, Oas F, Carvalho DM, et al. Effect of type 2 diabetes mellitus on the pharmacokinetics and transplacental transfer of nifedipine in hypertensive pregnant women[J]. British Journal of Clinical Pharmacology, 2017, 83(7)：1571-1572.
[11]谭晓蕾,彭勇.罗布麻茶的研究进展[J].中国现代中药,2014,16(8):666-673+680.
[12]唐敏,黄昆仑,罗云波,等.罗布麻叶与茶降血压效果比较实验研究[J]. 食品科技, 2013(11)：71-74.
[13]杨利,韩诗雯,车会莲,等.罗布麻茶水提物对自发性高血压大鼠血压的调节作用[J].中国食品学报,2017, 17(7)：55-60.
[14]王斐,韩吉春,李德芳,等.罗布麻总黄酮提取物抗心肌缺血再灌注损伤作用及其机制[J]. 药学服务与研究, 2018(1)：32-34.
[15]王东清,李国旗,程志.罗布麻研究利用现状及展望[J]. 江苏农业科学,2011,39(3)：310-313.
[16]刘晓云.原发性高血压与焦虑情绪的相关性研究[D].安徽医科大学,2017.
[17]王甜, 王萌, 蒋志惠,等. 罗布麻茶黄酮提取物对小鼠CYP2E1的影响[J]. 食品安全质量检测学报, 2014(6)：1608-1614.
[18]王佳, 谢健, 陈岳明,等.罗布麻叶总黄酮提取物对抑郁模型大鼠抗抑郁作用的研究[J].浙江医学,2016, 38(1)：14-16.

更新日期/Last Update: 2018-11-30