[1]夏涛.甲状旁腺激素(1-34)联合鲑鱼降钙素对绝经后骨质疏松压缩性骨折患者骨密度、骨代谢的影响[J].陕西医学杂志,2018,(11):1480-1482,1486.
　Xia Tao..Effect of parathyroid hormone (1-34) combined with salmon calcitonin injection on bone mineral density and bone metabolism in postmenopausal osteoporotic compression fractures[J].,2018,(11):1480-1482,1486.
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甲状旁腺激素(1-34)联合鲑鱼降钙素对绝经后骨质疏松压缩性骨折患者骨密度、骨代谢的影响

《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1480-1482,1486
栏目:
药物与临床
出版日期:
2018-11-29

文章信息/Info

Title:
Effect of parathyroid hormone (1-34) combined with salmon calcitonin injection on bone mineral density and bone metabolism in postmenopausal osteoporotic compression fractures
文章编号:
0.3969/j.issn.1000-7377.2018.11.034
作者:
夏涛
西安市第一医院（西安710002）
Author(s):
Xia Tao.
First Hospital of Xi’an(Xi’an 710002)
关键词:
骨质疏松/药物疗法甲状旁腺激素肽/治疗应用降钙素/治疗应用骨密度
Keywords:
Osteoporotic/drug therapyTeriparatide/therapeutic useCalcitonin/therapeutic useBone Density
分类号:
R642
文献标志码:
A
摘要:
目的：研究了甲状旁腺激素(1-34) \[PTH（1-34）\]联合鲑鱼降钙素针剂对绝经后骨质疏松(PMO)压缩性骨折患者骨密度、骨代谢的影响。方法：选择因PMO压缩性骨折进行治疗的患者120例，随机分为联合组和对照组，各60例。对照组在常规治疗的基础上使用鲑鱼降钙素注射液,联合组在对照组的基础上使用PTH（1-34），两组均治疗6个月。观察两组患者治疗前、治疗3个月和6个月时的骨密度、骨钙素（BGP）、β-胶原降解产物（β-CrossLaps）、骨碱性磷酸酶（BALP）、I型胶原羧基末端交联肽（CTX-1）、VAS和ODI评分的变化。结果：与联合组相比，治疗6个月后，对照组腰椎和大转子的骨密度显著较低（P＜0.05），股骨颈的骨密度没有统计学差异（P＞0.05）；对照组BGP和BALP的变化显著较低（P＜0.05）,β-CrossLaps和CTX-1的变化显著高于联合组（P＜0.05）；随着治疗时间的增长，两组患者的VAS和ODI评分显著降低（P＜0.05），治疗3个月和6个月时，与联合组相比，对照组的VAS和ODI评分显著较高（P＜0.05）。结论：PTH（1-34）和鲑鱼降钙素针剂联合使用能够显著增加患者骨密度，提高骨代谢中BGP和BALP含量，降低β-CrossLaps和CTX-1含量，改善患者的疼痛程度及生活质量。
Abstract:
Objective：The effect of parathyroid hormone (1-34) combined with salmon calcitonin injection on bone mineral density and bone metabolism in postmenopausal osteoporotic compression fractures were studied in this paper. Methods：120 patients who had compression fractures of PMO were randomly divided into a combination group and a control group, 60 cases each. In the control group, salmon calcitonin injection was used on the basis of conventional treatment, and PTH (1-34) was used in the combined group on the basis of the control group. Both groups were treated for 6 months. Changes in bone mineral density, BGP, β-CrossLaps, BALP, CTX-1, VAS, and ODI scores were observed before and at 3 and 6 months of treatment in both groups.Results：Compared with the combination group, after 6 months of treatment, the bone density of the lumbar spine and greater trochanter in the control group was significantly lower (P＜0.05), and the bone mineral density of the femoral neck was not statistically different (P＞0.05). The changes of BGP and BALP in the control group were significantly lower (P＜0.05), and the changes of β-CrossLaps and CTX-1 were significantly higher than that of the combined group (P＜0.05). Compared with the combination group, the VAS and ODI scores of the two groups decreased significantly with the increase of treatment time (P＜0.05). At 3 months and 6 months of treatment, compared with the combined group, the VAS of the control group and ODI score was significantly higher (P＜0.05). Conclusion：The combination of PTH (1-34) and salmon calcitonin injection can significantly increase bone mineral density, increase BGP and BALP content in bone metabolism, reduce β-CrossLaps and CTX-1 levels, and improve the patient's pain and quality of life, which could be widely used in the clinical application.

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更新日期/Last Update: 2018-11-30