[1]王延辉,薛瑞△,袁杰,等.鼠神经生长因子联合糖皮质激素治疗急性前庭神经炎疗效研究*[J].陕西医学杂志,2018,(11):1474-1476.
　Wang Yanhui,Xue Rui,Yuan Jie,et al.Effect of rat nerve growth factor combined with glucocorticoid in the treatment of acute vestibular neuritis[J].,2018,(11):1474-1476.
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鼠神经生长因子联合糖皮质激素治疗急性前庭神经炎疗效研究*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1474-1476
栏目:
药物与临床
出版日期:
2018-11-29

文章信息/Info

Title:
Effect of rat nerve growth factor combined with glucocorticoid in the treatment of acute vestibular neuritis
文章编号:
0.3969/j.issn.1000-7377.2018.11.032
作者:
王延辉1; 薛瑞2△; 袁杰1; 刘珂1
1.西安市第三医院耳鼻咽喉头颈外科(西安 710018）,2.西安市中心医院耳鼻咽喉头颈外科(西安710003）
Author(s):
Wang Yanhui; Xue Rui; Yuan Jie;  et al.
Department of ENT, Xi’an Third Hospital（Xi’an 710018）
关键词:
前庭神经炎/药物疗法 糖皮质激素/治疗应用神经生长因子类/治疗应用
Keywords:
Vestibular neuronitis/drug therapyGlucocorticoids/therapeutic useNerve growth factors/therapeutic use
分类号:
R764.34
文献标志码:
A
摘要:
目的：探讨鼠神经生长因子联合糖皮质激素在急性前庭神经炎治疗中的效果。方法：对72例急性前庭神经炎患者随机分为两组，对照组36例给予常规治疗:全身静脉滴注地塞米松15 mg/d,1周后,泼尼松片1 mg/（kg·d）,早服,每3 d减少1次，每次减量10 mg；治疗组36例在常规治疗的基础上加用注射用鼠神经生长因子３0 μg肌肉注射,1次/d，连续14 d。治疗前、治疗后第7、14天应用冷热试验和眩晕障碍量表（DHI）进行疗效评估。结果：对照组糖皮质激素治疗14 d后DHI 评分平均值为（15.71±14.58）、冷热试验CP值平均值（29.64±23.30），症状评分均有明显改善( P＜0. 05)，提示糖皮质激素治疗急性前庭神经炎有较好的疗效。治疗组患者在糖皮质激素治疗基础上加用鼠神经生长因子, 14 d后 DHI 评分平均值为（8.63±16.43）分、冷热试验CP值平均值为（24.78±22.57）。与对照组相比，冷热试验CP值、DHI 评分在两组间差异具有统计学意义（P＜0.05）。结论：急性前庭神经炎在常规糖皮质激素治疗基础上加用注射用鼠神经生长因子，能够有效改善患者的临床症状,且安全性较高。
Abstract:
Objective：To investigate the effect of rat nerve growth factor combined with glucocorticoid in the treatment of acute vestibular neuritis. Methods：72 cases Acute vestibular neuritis patients were randomly divided into two groups, control group 36 cases were given conventional treatment: systemic intravenous drip dexamethasone 15 mg/d, after 1 week, prednisone piece 1 mg/(kg/d), early, once every 3 d reduced by 1, each time 10 mg reducing; Thirty-six patients in the treatment group received one /d intramuscular injection with rat neurogrowth factor 30, which was used for injection on the basis of routine treatment for 14 consecutive days. Before and 14 days after treatment, the therapeutic effect was evaluated by cold and heat test and vertigo disorder scale (DHI).Results：Control group glucocorticoid treatment after 14 days DHI average score was （15.71±14.58）, cold and hot test CP value average （29.64±23.30）, symptom scores were improved significantly (P＜0. 05), prompt glucocorticoid treatment of acute vestibular neuritis had good curative effect. In the treatment group, rat nerve growth factor was added on the basis of glucocorticoid treatment, and the mean value of DHI score after 14 days was （8.63±16.43）points, and CP value of cold and heat test was （24.78±22.57）points. Cold and hot test, compared with the control group, CP value, DHI score in a statistically significant difference between the two groups, prompt mouse nerve growth factor with glucocorticoid therapy of acute vestibular neuritis of subjective or objective examination has good curative effect, and clinical effect is better than using glucocorticoid therapy alone. Conclusion：It is worthy of clinical application to improve clinical symptoms and safety of the patients in the treatment of Acute vestibular neuritis .

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备注/Memo

备注/Memo:
*西安市科技计划项目\[2017116SF/YX010(9)\]
更新日期/Last Update: 2018-11-30