[1]余明,王博,张亚飞,等.癌前病变及胃癌与幽门螺杆菌感染的关系探讨*[J].陕西医学杂志,2018,(11):1424-1426.
　Yu Ming,Wang Bo,Zhang Yafei,et al.Relationship between precancerous lesion and gastric cancer and helicobacter pylori infection[J].,2018,(11):1424-1426.
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癌前病变及胃癌与幽门螺杆菌感染的关系探讨*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1424-1426
栏目:
临床研究
出版日期:
2018-11-29

文章信息/Info

Title:
Relationship between precancerous lesion and gastric cancer and helicobacter pylori infection
文章编号:
0.3969/j.issn.1000-7377.2018.11.017
作者:
余明1; 王博2; 张亚飞2; 田延龙2 ; 刘娟妮2; 李俊海2△
1.陕西中医药大学（咸阳 712000）,2.陕西省核工业二一五医院（咸阳 712000）
Author(s):
Yu Ming; Wang Bo; Zhang Yafei; et al.
Shaanxi University of Chinese Medicine（Xianyang 712000）
关键词:
幽门螺杆菌胃炎; 肥厚性胃炎; 萎缩性胃肿瘤 因果律
Keywords:
Helicobacter pyloriGastritis;  hypertrophicGastritis;  atrophicGastric neoplasmsCausality
分类号:
R573
文献标志码:
A
摘要:
目的：探讨慢性浅表性胃炎、癌前病变及胃癌与幽门螺杆菌(HP)感染的关系。方法：对100例慢性浅表性胃炎患者、100例癌前病变患者和60例胃癌患者进行HP检测及病理检测，选取同时期 40例健康体检人员作为对照组。比较慢性浅表性胃炎、癌前病变及胃癌与HP感染的关系。结果：健康人群、慢性浅表性胃炎患者、胃癌前病变和胃癌患者HP感染率为52.5%、56.0%、73.0%和90.0%；慢性浅表性胃炎HP感染率高于健康人群，但无统计学差异（P＞0.05）；癌前病变与胃癌患者的HP感染率明显高于健康人群（P＜0.05）；慢性浅表性胃炎、癌前病变患者与胃癌患者之间HP感染率差异具有统计学意义(P＜0.05)；癌前病变不同病理类型HP感染率差异有统计学意义(P＜0.05)；胃癌不同部位及不同分化程度HP感染率差异有统计学意义 (P＜0.05)。结论：胃癌前病变及胃癌患者HP感染率高，患病与HP感染有一定关系。所以应积极治疗HP感染人群，降低感染人群恶化风险。
Abstract:
Objective: To investigate the relationship between chronic superficial gastritis, precancerous lesions and gastric cancer and Helicobacter pylori (HP) infection. Methods: 100 cases of chronic superficial gastritis, 100 cases of precancerous lesions and 60 cases of gastric cancer were detected by HP and pathological examination. 40 cases of healthy physical examination personnel were selected as control group at the same time. The relationship between chronic superficial gastritis, precancerous lesions, and gastric cancer was compared with HP infection. Results: HP infection rate was 52.5%, 56.0%, 73.0%, and 90.0% in healthy people, patients with chronic superficial gastritis, precancerous lesions, and gastric cancer; the incidence of HP infection in chronic superficial gastritis was higher than that in healthy people, but there was no obvious difference (P＞0.05); HP infection rate in precancerous lesions and gastric cancer patients was significantly higher than that in healthy people (P＜0.05); the difference in HP infection rate between chronic superficial gastritis, precancerous lesions, and gastric cancer patients was statistically significant (P＜0.05); precancerous lesions differed significantly in pathological HP infection rate (P＜0.05); there was a significant difference in HP infection rates of different sites and different differentiation degrees of gastric cancer (P＜0.05). Conclusion: Precancerous lesions and gastric cancer patients have a high rate of HP infection and their prevalence is related to HP infection. Therefore, we should actively treat people infected with HP and reduce the risk of deterioration in infected people.

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备注/Memo

备注/Memo:
*陕西省咸阳市科学技术研究发展计划项目（2016K02-93）
更新日期/Last Update: 2018-11-30