[1]张春花,谭小兰,滕晓,等.重组促卵泡素β与高纯度尿促卵泡素对体外受精-胚胎移植结局的影响*[J].陕西医学杂志,2018,(11):1414-1416,1433.
　Zhang Chunhua,Tan Xiaolan,Teng Xiao,et al.To investigatethe effect of recombinant follicle stimulating hormone beta and high purity urinary follicle stimulating hormone on the outcome of in vitro fertilization-embryo transfer[J].,2018,(11):1414-1416,1433.
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重组促卵泡素β与高纯度尿促卵泡素对体外受精-胚胎移植结局的影响*
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《陕西医学杂志》[ISSN:1000-7377/CN:61-1281/TN]

卷:
期数:
2018年11期
页码:
1414-1416,1433
栏目:
临床研究
出版日期:
2018-11-29

文章信息/Info

Title:
To investigatethe effect of recombinant follicle stimulating hormone beta and high purity urinary follicle stimulating hormone on the outcome of in vitro fertilization-embryo transfer
文章编号:
0.3969/j.issn.1000-7377.2018.11.014
作者:
张春花; 谭小兰; 滕晓; 禤丽; 余绍玲; 莫毅
广西壮族自治区卫生计生委生殖中心(南宁 530021)
Author(s):
Zhang Chunhua; Tan Xiaolan; Teng Xiao; et al.Reproductive Center of
Guangxi Zhuang Autonomous Region Health and Family Planning Commission (Nanning 530021)
关键词:
体外受精胚胎移植妊娠结局@重组促卵泡素β@高纯度尿促卵泡素
Keywords:
Fertilization in vitroEmbryo transferPregnancy outcome@Recombinant follicle stimulating hormone beta@High purity urinary follicle stimulating hormone
分类号:
R737.31
文献标志码:
A
摘要:
目的：分析重组促卵泡素β(r-FSHβ）与高纯度尿促卵泡素（HP-uFSH）对体外受精-胚胎移植临床治疗结局的影响。方法：回顾分析行IVF-ET长方案助孕的患者511例，按促性腺激素（Gn）种类不同，分为r-FSHβ组297例，HP-uFSH组214例。比较两组患者的一般情况，基础FSH、LH、E2值、Gn启动量、Gn用药天数、Gn总量、获卵数、MⅡ数、胚胎数、优胚数、移植胚胎数、移植优胚数、临床妊娠率、流产率、OHSS发生率。结果：两组患者的一般情况，基础FSH、LH、E2值、移植胚胎数、移植优胚数、临床妊娠率、流产率、OHSS发生率差异无统计学意义（P＞0.05）。HP-uFSH组Gn启动量、Gn用药天数、Gn总量高于r-FSHβ组，而获卵数、MⅡ数、胚胎数、优胚数较r-FSHβ组少，差异有统计学意义（P＜0.01）。结论：在IVF-ET周期中，HP-uFSH和r-FSHβ具有相同的临床治疗结局，临床妊娠率、流产率无明显差异。
Abstract:
Objective：Analysis of the effect of recombinant follicle stimulating hormone beta(r-FSHβ)and high-purity urinary follicle stimulating hormone (HP-uFSH) on clinical treatment of in vitro fertilezation-embryo transfer.Methods：Retrospective analysis of 511 cases of IVF-ET long term assisted pregnancy, according to different types of gonadotropin (Gn).They were divided into r-FSHβgroup （297 cases）and HP-uFSH group（214 cases）.The general conditions,basic FSH,LH, E2 levels, Gn start doses,Gn medication days,Gn total doses, the numbers of oocytes retrieved, the numbers of MII oocytes,the numbesr of embryos,the numbers of optimal embryos,the numbers of transplanted embryos,the numbers of transplanted optimal embryos,clinical pregnancy rate,abortion rate and incidence of OHSS in the two groups were compared.Results：There was no significant difference in the general conditions,the basic FSH, LH, E2 levels,the numbers of transplanted embryos,the numbers of transplanted optimal embryos, clinical pregnancy rate, abortion rate and incidence of OHSS between the two groups (P＞0.05).The number of Gn start doses, Gn medication days, Gn total doses in group HP-uFSH were higher than those of r-FSHβgroup,but the numbers of oocytes retrieved,MII oocytes, embryos,optimal embryos were less than those of r-FSHβgroup,and the difference was statistically significant (P＜0.01).Conclusion：In the IVF-ET cycle,HP-uFSH and r-FSHβhad the same clinical treatment outcome, and there was no significant difference in clinical pregnancy rate and abortion rate.

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备注/Memo

备注/Memo:
广西壮族自治区卫生和计划生育委员会自筹经费课题（Z20170976）
更新日期/Last Update: 2018-11-30